MG149CAS号： 1243583-85-8分子式： C22H28O3分子量： 340.46描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
MG 149；MG-149；Tip60 HAT inhibitor
|
| 可溶性/溶解性 |
DMSO : ≥ 100 mg/mL (293.72 mM)
|
| 生物活性 | |
| 靶点 |
Histone Acetyltransferase
|
| In vitro(体外研究) |
MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05).
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分子结构图
