JH-X-119-01CAS号： 2227368-54-7分子式： C25H20N6O3分子量： 452.46描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
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| 纯度 |
97%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:12 mg/ml (26.52 mM)
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| 生物活性 | |
| 靶点 |
IRAK-1:9 nM
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| In vitro(体外研究) |
JH-X-119-01 exhibited cytotoxic activity at single digit micromolar concentrations in a panel of WM, DLBCL, and lymphoma cell lines expressing MYD88.?Cotreatment of JH-X-119-01 with the BTK inhibitor ibrutinib resulted in synergistic killing effects in these systems.
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