GSK-114 is a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM. GSK-114 shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral exposure to enable its use in cellular and in vivo studies.

98%

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