Mouse Monoclonal Antibody (Mab)

FLNA抗体;Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin; FLNA; FLN; FLN1

Mouse

Purified His-tagged FLNA protein was used to produced this monoclonal antibody.

Human, Mouse, Rat

IF~~1:25
WB~~1:1000

Predicted molecular weight: 281kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

1273CT424.104.153

IgG1

Maintain refrigerated at 2-8°C for up to 2 weeks. For long time storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Signal Transduction

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton

P21333

Gorlin J.B., et al. J. Cell Biol. 111:1089-1105(1990).
Patrosso M.C., et al. Genomics 21:71-76(1994).
Chen E.Y., et al. Hum. Mol. Genet. 5:659-668(1996).
Li J., et al. Mol. Cell. Proteomics 9:2517-2528(2010).
Ota T., et al. Nat. Genet. 36:40-45(2004).