GDC0994CAS号： 1453848-26-4分子式： C21H18ClFN6O2分子量： 440.87描述纯度储存/保存方法别名可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
GDC-0994,Ravoxertinib
|
| 可溶性/溶解性 |
DMSO 87 mg/mL (197.79 mM)
Ethanol 87 mg/mL (197.79 mM) |
| 生物活性 | |
| 靶点 |
ERK
|
| In vivo(体内研究) |
In CD-1 mice, a 10 mg/kg oral dose of GDC-0994 is sufficient to achieve the desired target coverage for at least 8 h. Daily, oral dosing of GDC-0994 results in significant single-agent activity in multiple in vivo cancer models, including KRAS-mutant and BRAF-mutant human xenograft tumors in mice.
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分子结构图
