GLPG0974CAS号： 1391076-61-1分子式： C25H25ClN2O4S分子量： 484.99描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:180mg/mL (371.1mM)
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| 生物活性 | |
| 靶点 |
GPR43:9 nM
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| In vitro(体外研究) |
GLPG0974 inhibits acetate-induced neutrophil migration strongly and inhibits CD11b activation-specific epitope [AE], a neutrophil-based pharmacodynamic marker, in a human whole blood assay[1].
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| In vivo(体内研究) |
GLPG0974(5 and 30 mg/kg; oral) exhibits good pharmacokinetic properties in rat with a bioavailability of 47% and dose-dependently increases the plasma exposure[1].
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