FK962CAS号： 283167-06-6 分子式： C14H17FN2O2分子量： 264.30描述纯度储存/保存方法别名靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
N-(1-acetyl-4-piperidinyl)-4-fluoro-BenzaMide
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| 生物活性 | |
| 靶点 |
Somatostatin release
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| In vitro(体外研究) |
FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
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| In vivo(体内研究) |
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer’s disease.
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分子结构图
