GSK319347ACAS号： 862812-98-4分子式： C22H19N3O5S2分子量： 469.53描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
CAY10576；IKK-3 Inhibitor
|
| 可溶性/溶解性 |
DMSO : 45 mg/mL (95.84 mM; Need ultrasonic)
|
| 生物活性 | |
| 靶点 |
TBK1；IKK-ε；IKK2
|
| In vitro(体外研究) |
GSK319347A (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM.
|
分子结构图
