NCGC00092410CAS号： 442898-34-2分子式： C21H27N3O2分子量： 353.46描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
NCGC00092410 is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:37.5 mg/mL (106.1 mM)
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| 生物活性 | |
| 靶点 |
glucocerebrosidase:31 nM
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| In vitro(体外研究) |
NCGC00092410 increased GC activity in N370S mutant fibroblasts. Treatment of Gaucher’s fibroblasts with 40μM NCGC00092410 for 10-70 h increased the lysosomal content of GC in Gaucher’s fibroblasts. NCGC00092410 inhibited GC activity with different substrate concentrations in a dose-dependent manner. [1].
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