RO 106-9920 is a cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. RO 106-9920 acts as a highly selective, irreversible inhibitor of IκBaee ubiquitination. RO 106-9920 blocks NF-κB-dependent cytokine expression in human PBMNs and rats. RO 106-9920 does not inhibit SCFbTRCP (IκBa ubiquitin ligase)-mediated b-catenin ubiquitination in Jurkat cells. At 10 μM concentrations, this compound also inhibits the activities of 5-LO (5-lipoxygenase), EGFR kinase and NOS2 (iNOS).

≥95%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

6-(phenylsulfinyl)-tetrazolo[1,5-b]pyridazine

white

IκBαee ubiquitination: IC₅₀ = 2.3 µM; TNF-α, IL-1β, and IL-6: IC₅₀ = ~700 nM (human PBMNs)

Soluble in ethanol (5 mM), DMSO (12 mg/ml), and water (6.32 mg/ml) at 25° C.