Enniatin B is an ionophore antibiotic and fungal metabolite generated by multiple Fusarium strains. Studies indicate that Enniatin B has cytotoxic activity in vitro, but no genotoxic activity. Enniatin B has been shown to inhibit the Pdr5p ABC transporter in Saccharomyces cerevisiae, as well as acyl-CoA-cholesterol acyltransferase (ACAT). Additionally, joint studies of valinomycin and enniatin B have demonstrated that they can bind to calmodulin (CaM) and inhibit the activity of 3′,5′-cyclic nucleotide phosphodiesterase (PDE). It is believed that enniatin B possess anticancer properties.

Fusariumsp.

An ionophore antibiotic that inhibits ACAT and PDE

≥98%

Store at -20° C

Solid

~1.0 g/cm³ (Predicted)

175-175.3° C

~827.0° C at 760 mmHg (Predicted)

n²⁰_D 1.46 (Predicted)

Mycobacterium tuberculosis H37Rv: IC₅₀ = 7.26 µM

Soluble in water (700 mg/L at 25 °C), chloroform (44.51 g/100mL at 25 °C), dichloromethane (19.20 g/100mL at 25 °C), methanol (9.98 g/100mL at 25 °C), DMSO (50 mM), ethanol (1.28 g/100mL at 25 °C)

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