MPP+ iodide is a metabolite of dopaminergic neurotoxin MPTP which stimulates the production of the superoxide radical resulting in apoptosis in PC12 cells. Studies suggest that MPP+ iodide is a selective inhibitor of mitochondrial complex I and it decreases mitochondrial REDOX activity. In addition, GSK-3β is a mediator of MPP+ iodide induced neurotoxicity. Alternate studies indicate that the D-loop of human mtDNA is destabilized by MPP+ iodide via releasing the nascent H-strands of mtDNA.

An active metabolite of the dopaminergic neurotoxin MPTP

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

1-甲基-4-苯基吡啶碘化物；1-Methyl-4-phenylpyridinium iodide

Tan to yellow solid

DMSO : 100 mg/mL (336.54 mM; Need ultrasonic)
H2O : 100 mg/mL (336.54 mM; Need ultrasonic)

MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells. MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity.