PF-5190457CAS号： 1334782-79-4分子式： C29H32N6OS分子量： 512.67描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
|
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 可溶性/溶解性 |
DMSO:250 mg/mL (487.64 mM)
|
| 生物活性 | |
| 靶点 |
ghrelin receptor:8.36 (pKi)
|
| In vitro(体外研究) |
PF-5190457 has a superior balance of ghrelin receptor pharmacology. It also has off-target selectivity [1].
|
| In vivo(体内研究) |
In human whole and dispersed islets, PF-5190457 has excellent selectivity and demonstrates robust increases in glucose-stimulated insulin secretion[1].
|