NGB 2904CAS号： 189060-98-8分子式： C28H29Cl2N3O•HCl分子量： 530.92描述应用储存/保存方法形态熔点沸点折射率IC50Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
NGB 2904 is a highly-selective D3DR antagonist (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3DR, D2DR, 5-HT2, α1, D4DR, D1DR and D5DR receptors respectively), with antagonistic effects against quinpirole-stimulated mitogenesis (IC50 = 6.8 nM).
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| 应用 |
A highly-selective D3DR antagonist
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| 储存/保存方法 |
Desiccate at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 熔点 |
273-274° C
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| 沸点 |
708.8° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.63 (Predicted)
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| IC50 |
D3DR: IC50 = 5 nM (human); CHO-hD3: IC50 = 5 nM (rat); Quinpirole-stimulated mitogenesis: IC50 = 6.8 nM; D2DR: IC50 = 1.28 µM (human)
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| Ki 数据 |
Dopamine D3 receptor: Ki= 1.1 nM (rat); D2DR: Ki= 112 nM (human); Serotonin 2 (5-HT2) receptor: Ki= 223 nM (rat); SR-2C: Ki= 411 nM (human); Adrenergic receptor α-1: Ki= 642 nM (rat)
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| 可溶性/溶解性 |
Soluble in ethanol (5 mM), and DMSO (≥25 mg/ml).
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| MDL |
MFCD09971107
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| PubChem CID |
19366304
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