IDH889CAS号： 1429179-07-6分子式： C23H25FN6O2分子量： 436.48描述储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:60 mg/ml (137.46 mM)
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| 生物活性 | |
| 靶点 |
IDH1WT:1.38 μM, IDH1R132H:0.02 μM, IDH1R132C:0.072 μM
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| In vitro(体外研究) |
IDH889 displays effective cellular inhibition of R-2-hydroxyglutarate (2-HG) production (IC50: 0.014 μM).
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