VorasidenibCAS号： 1644545-52-7分子式： C14H13ClF6N6分子量： 414.74描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
Vorasidenib 是一个非特异的异柠檬酸脱氢酶 (IDH) 抑制剂。 |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
AG-881；AG881
|
| 外观 |
Solid powder
|
| 可溶性/溶解性 |
DMSO : ≥ 125 mg/mL (301.39 mM)
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| 生物活性 | |
| 靶点 |
IDH
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| In vitro(体外研究) |
Vorasidenib has recently entered phase 1 clinical trials in hematologic (NCT02492737) and solid malignancies (NCT02481154) in patients with either an IDH1 or an IDH2 mutation. Preclinical studies have suggested that Vorasidenib fully penetrates the blood-brain barrier and may be a more effective option for patients with IDH1/2 mutated glioma.
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分子结构图
