NMS-873CAS号： 1418013-75-8分子式： C27H28N4O3S2分子量： 520.67描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).
|
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
NMS873; NMS 873
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO 100 mg/mL (192.06 mM)
|
| 生物活性 | |
| 靶点 |
p97
|
| In vitro(体外研究) |
NMS-873 reduces p97 sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873, as a p97 inhibitor, produces antiproliferative activity in a variety of hematological and solid tumor lines. The mechanism study indicates that NMS-873 activates the unfolded protein response, interfers with autophagy and thus induces cancer cell death.
|
分子结构图
