Mouse Monoclonal Antibody (Mab)

UCH37抗体;Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH-L5; Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5; UCHL5; UCH37

Mouse

Purified His-tagged UCH37 protein was used to produced this monoclonal antibody.

Human

WB~~1:1000

Predicted molecular weight: 38kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

854CT5.5.6

IgG1

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Cell Biology

Protease that specifically cleaves ‘Lys-48’-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus

Q9Y5K5

Yao T., et al. Nat. Cell Biol. 8:994-1002(2006).
Lai C.-H., et al. Genome Res. 10:703-713(2000).
Hu R.-M., et al. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Gregory S.G., et al. Nature 441:315-321(2006).