3-Deazauridine is a nucleoside analog. It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia. It also enhances the incorporation of decitabine  into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

4-羟基-1-Β-D-呋喃核糖苷-2(1H)吡啶酮；4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone；NSC 126849

White to Pale Beige Solid

DMF: 16 mg/ml
DMSO: 10 mg/ml