AG 825 is shown to be a potent inhibitor of EGFR (epidermal growth factor receptor) and Neu (HER-2) kinases. Mechanistic studies report that this compound inhibits mitogenic signaling elements downstream to the growth receptor kinase. Studies indicate that inhibition of HER-2 causes imbalance between extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase activation. It has also been observed that treatment of cells with AG 825 results in apoptosis induction and inhibition of colony formation.

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

Tyrphostin C15

yellow

HER1-2 tyrosine kinase : IC₅₀ = 0.35 µM; EGFR: IC₅₀ = 19 µM; PDGFR: IC₅₀ = 40 µM

Soluble in DMSO (25 mg/ml), methanol, ethanol (~0.2 mg/ml), DMF (~30 mg/ml), and 1:3 solution of DMSO:PBS (pH 7.2) (~0.1 mg/ml).