Capmatinib(INCB28060)CAS号： 1029712-80-8分子式： C23H17FN6O分子量： 412.42描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
INCB 28060; INCB-28060; INC280
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| 外观 |
Powder
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| 可溶性/溶解性 |
DMSO 2 mg/mL (4.84 mM)
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| 生物活性 | |
| 靶点 |
c-Met
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| In vitro(体外研究) |
INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration.
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| In vivo(体内研究) |
INCB28060 shows strong antitumor activity in c-MET-dependent mouse tumor models, even oral treatment of 0.03 mg/kg INCB28060 causes approximately 50% inhibition of c-MET-phosphorylation. Dose-dependent inhibition of tumor growth is observed in tumor-bearing mice.
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分子结构图
