Indirubin Derivative E804 is a cell-permeable indirubin derivative (IDR) that inhibits the Src-Stat3 signaling pathway and displays anti-tumor properties. A potent, ATP-competitive inhibitor of the kinase activities of Src. Indirubin Derivative E804 decreases tyrosine phosphorylation levels of Src, JAK1, and Stat3 in MDA-MB-468 cells in a time- and dose-dependent manner. Selectively induces apoptosis in cells expressing high levels of active Stat3. Indirubin Derivative E804 is an inhibitor of Cdc2, Cdk2 and SRC.

A cell-permeable inhibitor of Src-Stat3 signaling pathway

≥95%

Store at -20° C

Solid

IDR E804

1.4 g/cm³ (Predicted)

262.70° C (Predicted)

719.8° C at 760 mmHg (Predicted)

n²⁰_D 1.70 (Predicted)

pK_a: 10.55 (Predicted)

Soluble in DMSO (200 mg/ml).

6419764