LP-922761 is an effective, selective, and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor (IC50: 4.8 nM and a cellular IC50: 7.6 nM). LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) (IC50: 24 nM). LP-922761 shows no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2, or GABAa receptors.

97%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

BMP-2-inducible protein kinase BIKE:24 nM, AAK1:4.8 nM, AAK1 in cell assays:7.6 nM

LP-922761 has a brain to plasma ratio of 0.007, in the mouse. It indicating that LP-922761 is essentially restricted to the peripheral compartment.