Mouse Monoclonal Antibody (Mab)

NR3C1抗体;Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1; NR3C1; GRL

Mouse

This NR3C1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from human NR3C1.

Human, Mouse

WB~~1:1000

Predicted molecular weight: 86kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

740CT12.1.5

IgM,k

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Cancer;Signal Transduction

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

Cytoplasm. Mitochondrion. Nucleus Note=Cytoplasmic in the JPence of ligand, nuclear after ligand- binding

P04150

Hollenberg S.M., et al. Nature 318:635-641(1985).
Encio I.J., et al. J. Biol. Chem. 266:7182-7188(1991).
Wang W., et al. Nucleic Acids Res. 39:44-58(2011).
Turner J.D., et al. Ann. N. Y. Acad. Sci. 1095:334-341(2007).
Munroe D.G., et al. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.