NVP DPP 728 dihydrochlorideCAS号： 247016-69-9；207556-62-5分子式： C15H18N6O•2HCl分子量： 371.27描述纯度储存/保存方法别名外观可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
NVP DPP 728 is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
NVPDDP 728；NVP DPP728
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| 外观 |
Powder
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| 可溶性/溶解性 |
Water ： ≥ 40 mg/mL
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| 生物活性 | |
| In vitro(体外研究) |
NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases.
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| In vivo(体内研究) |
NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1.
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分子结构图
