Rabbit anti-Phospho-IRE1(Ser724) Monoclonal Antibody(3I5)别名宿主反应种属应用分子量免疫原形式纯化方法克隆号同种型储存/保存方法存储溶液修饰背景说明UniProt
| 概述 | |
| 别名 |
ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
|
| 宿主 |
Rabbit
|
| 反应种属 |
Human
|
| 应用 |
WB: 1/500-1/1000
|
| 分子量 |
Detects a band of approximately 110 kD(Predicted molecular weight: 110 kD)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 |
A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1
|
| 性能 | |
| 形式 |
Monoclonal Antibody
|
| 纯化方法 |
Affinity Purified
|
| 克隆号 |
3I5
|
| 同种型 |
IgG
|
| 储存/保存方法 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
|
| 存储溶液 |
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
|
| 修饰 |
Phosphorylated
|
| 靶标 | |
| 背景说明 |
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
|
| UniProt |
O75460
|
实验结果图
Western blot analysis of IRE1 (Phospho-Ser724) in K562 lysates using Phospho-IRE1 (Ser724) antibody.