Rabbit anti-Phospho-IRE1(Ser724) Polyclonal Antibody别名宿主反应种属应用分子量免疫原形式纯化方法同种型储存/保存方法存储溶液修饰背景说明UniProt
| 概述 | |
| 别名 |
ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
|
| 宿主 |
Rabbit
|
| 反应种属 |
Human
|
| 应用 |
WB: 1/500-1/1000
|
| 分子量 |
Detects a band of approximately 110 kD(Predicted molecular weight: 110 kD)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 免疫原 |
A synthesized peptide derived from human Phospho-IRE1 (S724)
|
| 性能 | |
| 形式 |
Polyclonal Antibody
|
| 纯化方法 |
Affinity Chromatography
|
| 同种型 |
IgG
|
| 储存/保存方法 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
|
| 存储溶液 |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
| 修饰 |
Phosphorylated
|
| 靶标 | |
| 背景说明 |
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
|
| UniProt |
O75460
|
实验结果图
Western blot analysis of Phospho-IRE1 (S724) in (1) K562 lysates treated with AP; (2) Untreated K562 lysates using Phospho-IRE1 (Ser724) antibody.