FTY720-d4 Hydrochloride CAS号: 1346604-90-7分子式: C19H30D4ClNO2分子量: 347.96描述储存/保存方法别名外观可溶性/溶解性参考文献
产品描述 | |
描述 |
A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
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储存/保存方法 |
Refrigerator
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基本信息 | |
别名 |
2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-d4 Hydrochloride; Fingolimod-d4 Hydrochloride;
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外观 |
White Solid
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可溶性/溶解性 |
DMSO, Methanol
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参考文献 | |
参考文献 |
Brinkmann, V., et al.: Transplantation, 72, 764 (2001), Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002), Mtaloubian, M., et al.: Nature, 427, 355 (2004),
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