AJ-97166CAS号： 746667-48-1分子式： C17H13N5分子量： 287.32描述纯度储存/保存方法别名外观可溶性/溶解性In vitro(体外研究)
| 产品描述 | |
| 描述 |
AJ-97166 is a novel potent antagonist of the TGFbeta family type I receptors, Alk5 and/or Alk4. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
BIO-013077-01；Quinoxaline
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO
|
| 生物活性 | |
| In vitro(体外研究) |
A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies.
|
分子结构图
