GRI977143 CAS号： 325850-81-5分子式： C22H17NO4S分子量： 391.44描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
GRI977143 is a specific LPA2 receptor agonist, with an EC50 of 3.3 μM.
|
| 纯度 |
95%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
GRI-977143
|
| 外观 |
white to light brown powder
|
| 可溶性/溶解性 |
DMSO : 50 mg/mL (127.73 mM; Need ultrasonic)
|
| 生物活性 | |
| 靶点 |
LPA2 Receptor
|
| In vitro(体外研究) |
GRI977143 (10 μM, 24-72 h) is effective in reducing activation of caspases 3, 7, 8, and 9 and inhibits poly(ADP-ribose)polymerase 1 cleavage and DNA fragmentation in different extrinsic and intrinsic models of apoptosis.
GRI977143 is an effective stimulator of extracellular signal-regulated kinase 1/2 activation and promotes the assembly of a macromolecular signaling complex consisting of LPA2, Na+-H+ exchange regulatory factor 2, and thyroid receptor interacting protein 6. |
分子结构图
