PF06840003CAS号： 198474-05-4分子式： C12H9FN2O2分子量： 232.21描述纯度储存/保存方法别名外观靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
PF-06840003 is an orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1),with potential immunomodulating and antineoplastic activities.
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| 纯度 |
>98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
PF 06840003,PF-06840003
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| 外观 |
Powder
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| 生物活性 | |
| 靶点 |
Indoleamine 2,3-Dioxygenase (IDO)
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| In vitro(体外研究) |
PF-06840003 reverses IDO-1-induced T-cell anergy in vitro.
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| In vivo(体内研究) |
PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours.
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分子结构图
