Methylnitrosourea

MethylnitrosoureaCAS号: 684-93-5分子式: C2H5N3O2分子量: 103.08描述纯度储存/保存方法别名可溶性/溶解性In vitro(体外研究)In vivo(体内研究)

产品描述
描述
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane.
纯度
98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
别名
1-甲基-1-亚硝基脲;N-亚硝基-N-甲基脲;NMU;MNU;NMH
可溶性/溶解性
DMSO : 125 mg/mL (1212.65 mM; Need ultrasonic)
生物活性
In vitro(体外研究)
N-Nitroso-N-methylurea (NMU; 5 μM) treatment increases the cellular NF-κB activity in human malignant keratinocytes. N-Nitroso-N-methylurea also increases the amount of I-κBα phosphorylation.
In vivo(体内研究)
N-Nitroso-N-methylurea (NMU) gives intravenously to rats at age 50 days induced mammary carcinomas in 89% of BUF/N, 73% of Sprague-Dawley, and 89% of F344 females. Latent periods are, respectively, 77, 86, and 94 days. Doubling times of NMU-induced primary and transplanted carcinomas are similar to 7 days. Cachexia ensues at the 5th week from the onset of the first tumor. When the tumor is larger than 15 g, hypercalcemia is usually observed.

分子结构图

Methylnitrosourea