MethylnitrosoureaCAS号: 684-93-5分子式: C2H5N3O2分子量: 103.08描述纯度储存/保存方法别名可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
产品描述 | |
描述 |
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane.
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
1-甲基-1-亚硝基脲;N-亚硝基-N-甲基脲;NMU;MNU;NMH
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可溶性/溶解性 |
DMSO : 125 mg/mL (1212.65 mM; Need ultrasonic)
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生物活性 | |
In vitro(体外研究) |
N-Nitroso-N-methylurea (NMU; 5 μM) treatment increases the cellular NF-κB activity in human malignant keratinocytes. N-Nitroso-N-methylurea also increases the amount of I-κBα phosphorylation.
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In vivo(体内研究) |
N-Nitroso-N-methylurea (NMU) gives intravenously to rats at age 50 days induced mammary carcinomas in 89% of BUF/N, 73% of Sprague-Dawley, and 89% of F344 females. Latent periods are, respectively, 77, 86, and 94 days. Doubling times of NMU-induced primary and transplanted carcinomas are similar to 7 days. Cachexia ensues at the 5th week from the onset of the first tumor. When the tumor is larger than 15 g, hypercalcemia is usually observed.
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分子结构图