Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. CAY10677 is an analog of the Icmt inhibitor cysmethynil (Item No. 14745) that was developed for improved solubility and cell permeability.¹ CAY10677 inhibits Icmt with an IC₅₀ value of 0.86 μM and demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC₅₀s = 2.63 versus 27.4 μM, respectively) and human prostate cancer PC3 cells (IC₅₀s = 2.55 versus 25.2 μM, respectively).¹

≥98%

Store at -20℃

Icmt Inhibitor 15;

1.Ramanujulu, P.M.,Yang, T.,Yap, S.Q., et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). European Journal of Medicinal Chemistry 63, 378-386 (2013).