CM-675CAS号: 1872466-47-1分子式: C31H32N6O3分子量: 536.62描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
产品描述 | |
描述 |
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease.
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
可溶性/溶解性 |
DMSO:22.5mg/mL (41.9mM)
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生物活性 | |
靶点 |
PDE5:114 nM nM
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In vitro(体外研究) |
CM-675 (29a) exhibits a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours), and 69 nM (6 hours)[1].
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