CM-675

CM-675CAS号: 1872466-47-1分子式: C31H32N6O3分子量: 536.62描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)

产品描述
描述
CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to treat Alzheimer’s disease.
纯度
98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:22.5mg/mL (41.9mM)
生物活性
靶点
PDE5:114 nM nM
In vitro(体外研究)
CM-675 (29a) exhibits a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours), and 69 nM (6 hours)[1].