HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively[1].

A selective and potent TRPV4 antagonist

≥98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

White to tan powder

1.24 g/cm³ (Predicted)

259.54 °C (Predicted)

536.43 °C at 760 mmHg (Predicted)

n²⁰_D 1.57 (Predicted)

TRPV4: IC₅₀ = 17 nM (mouse); hERG channel: IC₅₀ = 370 nM; TRPM8 : IC₅₀ = 780 nM; Endogenous TRPV4-mediated response to 4α-PDH: IC₅₀ = 22 nM

DMSO : 50 mg/mL (106.04 mM; Need ultrasonic)

MFCD01571257

2742550

TRPV4