L-655,708CAS号： 130477-52-0分子式： C18H19N3O4分子量： 341.37描述应用纯度储存/保存方法形态别名密度熔点沸点折射率PK值Ki 数据可溶性/溶解性MDLPubChem CID
| 产品描述 | |
| 描述 |
L-655,708 is a potent and selective inverse agonist for the benzodiazepine site of GABAA R alpha5 (μ5-containing GABAA receptors). Displays high selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2.
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| 应用 |
A potent and selective inverse agonist for the benzodiazepine
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| 纯度 |
≥98%
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| 储存/保存方法 |
Desiccate at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate; L-655708
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| 密度 |
~1.4 g/cm3 (Predicted)
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| 熔点 |
193-195° C
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| 沸点 |
~584.4° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.68 (Predicted)
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| PK值 |
pKb: 1.50
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| Ki 数据 |
GABA receptor beta-3 subunit: Ki= 0.4 nM (human); GABA receptor gamma-2 subunit: Ki= 0.4 nM (human); GABA receptor alpha-5 subunit: Ki= 0.4 nM (human)
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| 可溶性/溶解性 |
Soluble in DMSO (5 mM), and 1eq. HCl (10 mM). Insoluble in water.
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| MDL |
MFCD02684528
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| PubChem CID |
5311203
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