VU 0469650CAS号： 1443748-47-7分子式： C22H28N4O分子量： 364.48描述纯度储存/保存方法可溶性/溶解性靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).
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| 纯度 |
97%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:90.0 mg/mL (224.5 mM)
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| 生物活性 | |
| 靶点 |
mGlu1:99 nM
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| In vivo(体内研究) |
VU 0469650 (10 mg/kg; I.P.; once; male Sprague-Dawley rats) shows an excellent selectivity profile and good exposure in both plasma and brain samples.[1] VU 0469650 (0.2 mg/kg; I.V.; once; male Sprague-Dawley rats) exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour.[1]
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