TBB(NSC 231634)CAS号: 17374-26-4分子式: C6HBr4N3分子量: 434.71描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
产品描述 | |
描述 |
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
纯度 |
>98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
NSC 231634;TBB (enzyme inhibitor);4,5,6,7-四溴-1H-苯并三唑
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外观 |
白色固体
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可溶性/溶解性 |
Ethanol : 100 mM
DMSO : ≥430 mg/mL |
生物活性 | |
靶点 |
CK2 ,CK1
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In vitro(体外研究) |
In the presence of 10 μM TBB (and 100 μM ATP) only CK2 was drastically inhibited (s85%) whereas three kinases (phosphorylase kinase, glycogen synthase kinase 3L and cyclin-dependent kinase 2/cyclin A) underwent moderate inhibition, with IC50 values one-two orders of magnitude higher than CK2 (IC50 = 0.9 μM). TBB discriminates between CK2 and CK1, being much more e¡ective with the former.
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In vivo(体内研究) |
The extent of retinal neovascularization in a mouse OIR model is reduced by approximately 60% after treatment with TBB (6 days at 60 mg/kg per day).
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参考文献 | |
参考文献 |
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分子结构图