TBB(NSC 231634)

TBB(NSC 231634)CAS号: 17374-26-4分子式: C6HBr4N3分子量: 434.71描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献

产品描述
描述

TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively).

纯度
>98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
别名
NSC 231634;TBB (enzyme inhibitor);4,5,6,7-四溴-1H-苯并三唑
外观
白色固体
可溶性/溶解性
Ethanol : 100 mM

DMSO : ≥430 mg/mL

生物活性
靶点
CK2 ,CK1
In vitro(体外研究)
In the presence of 10 μM TBB (and 100 μM ATP) only CK2 was drastically inhibited (s85%) whereas three kinases (phosphorylase kinase, glycogen synthase kinase 3L and cyclin-dependent kinase 2/cyclin A) underwent moderate inhibition, with IC50 values one-two orders of magnitude higher than CK2 (IC50 = 0.9 μM). TBB discriminates between CK2 and CK1, being much more e¡ective with the former.
In vivo(体内研究)
The extent of retinal neovascularization in a mouse OIR model is reduced by approximately 60% after treatment with TBB (6 days at 60 mg/kg per day).
参考文献
参考文献
  • 1. Orzechowska E, et al. Oncol Rep. 2012 Jan;27(1):281-5.
  • 2. Nakanishi K, et al. Thromb Res. 2010 Dec;126(6):511-6.
  • 分子结构图

    TBB(NSC 231634)