CAY10625 CAS号: 137346-42-0分子式: C25H26N4O4分子量: 446.5描述储存/保存方法形态密度沸点折射率IC50可溶性/溶解性MDLPubChem CID
产品描述 | |
描述 |
7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/Diablo, exhibiting an IC50 value of 2.2 µM. It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 μM. Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/Diablo, caspase-3, and caspase-7. Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. 7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.
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储存/保存方法 |
Store at -20° C
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形态 |
Solid
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基本信息 | |
密度 |
~1.3 g/cm3 (Predicted)
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沸点 |
~599.6 °C at 760 mmHg (Predicted)
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折射率 |
n20D 1.65 (Predicted)
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IC50 |
interaction between survivin and the apoptosis-promoting protein Smac/Diablo: IC50 = 2.2 µM; KB : IC50 = 7.6 µM (human); L1210: IC50 = 9.6 µM (mouse); interaction of survivin with INCENP: IC50 = 20 µM
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可溶性/溶解性 |
Soluble in ethanol (~0.5 mg/ml), DMF (~30 mg/ml), and DMSO (~30 mg/ml).
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MDL |
MFCD18382127
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PubChem CID |
44306972
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