GSK621CAS号： 1346607-05-3分子式： C26H20ClN3O5分子量： 489.91描述纯度储存/保存方法外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
GSK621 is a specific and potent AMPK activator. |
| 纯度 |
99%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 外观 |
crystalline solid
|
| 可溶性/溶解性 |
DMSO ：97 mg/mL (198.00 mM)
|
| 生物活性 | |
| 靶点 |
AMPK
|
| In vitro(体外研究) |
In AML cell lines and primary AML samples, GSK621 markedly increases phosphorylation at AMPKα T172, a marker of AMPK activation. In a set of 20 cell lines, GSK621 reduces the proliferation of all 20 lines with IC50 ranged from 13-30 μM, and increases apoptosis in 17 (85%) lines. In addition, GSK621 also triggers autophagy, which partially contributes to AML cell death.
|
| In vivo(体内研究) |
In nude mice bearing MOLM-14 xenografts, GSK621 (30 mg/kg, i.p.) reduces leukemia growth and significantly extends survival by enhancing AMPK activity and the induction of apoptosis.
|
| 参考文献 | |
| 参考文献 |
[1] Sujobert P, et al. Cell Rep. 2015, 11(9), 1446-1457. |
分子结构图
