PR-619CAS号： 2645-32-1分子式： C7H5N5S2分子量： 223.28描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
2,6-Diamino-3,5-dithiocyanopyridine; PR 619; PR619
|
| 外观 |
White to off-white powder
|
| 可溶性/溶解性 |
DMSO : ≥ 21 mg/mL (94.05 mM)
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| 生物活性 | |
| 靶点 |
JOSD2,SENP6 core,UCH-L3,USP4,USP8
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| In vitro(体外研究) |
PR-619, a deubiquitylase inhibitor, prevents degradation, indicating KCa3.1 is targeted for degradation by ubiquitylation. In PR-619 treated cells, channel degradation is significantly inhibited with 87±1% of KCa3.1 still remaining after 24 hrs (n=3; P. Cell viability is determined by MTT assay and revealed that PR-619 exerted concentration-dependent cytotoxicity in a very narrow concentration range of 7-10 μM.
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分子结构图
