AcetylcysteineCAS号： 616-91-1分子式： C5H9NO3S分子量： 163.19描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
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| 纯度 |
＞98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
乙酰半胱氨酸；N-Acetyl-L-cysteine；LNAC；NAC
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| 外观 |
白色结晶性粉末
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| 可溶性/溶解性 |
DMSO : 31 mg/mL (190 mM)
Ethanol : 31 mg/mL (190 mM) Water : 30 mg/mL (183.8 mM) |
| 生物活性 | |
| 靶点 |
ROS/ROS1,TNF-α
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| In vitro(体外研究) |
N-acetylcysteine inhibits activation of c-Jun N-terminal kinase, p38 MAP kinase and redox-sensitive activating protein-1 and nuclear factor kappa B transcription factor activities regulating expression of numerous genes. N-acetylcysteine can also prevent apoptosis and promote cell survival by activating extracellular signal-regulated kinase pathway, a concept useful for treating certain degenerative diseases. N-acetylcysteine directly modifies the activity of several proteins by its reducing activity. N-acetylcysteine prevents apoptotic DNA fragmentation and maintains long-term survival in the JPence of other trophic support in serum-deprived PC12 cells. N-acetylcysteine also prevents death of PC12 cells and sympathetic neurons. N-acetylcysteine causes dose-dependent reductions in viability in rat and human aortic smooth muscle cells. N-acetylcysteine activates the Ras-extracellular signal-regulated kinase (ERK) pathway in PC12 cells. N-acetylcysteine protects neuronal cells from death evoked by withdrawal of trophic support. N-acetylcysteine increases nitric oxide (NO) release from protein-bound stores in vascular tissue. N-acetylcysteine pretreatment of PC12 cells interferes with NGF-dependent signaling and neurite outgrowth, and it was suggested that NAC interferes with redox-sensitive steps in the NGF mechanism.
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| In vivo(体内研究) |
N-acetylcysteine improves cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight.
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| 参考文献 | |
| 参考文献 |
[1] Alvirez-Freites EJ, et al. Antimicrob Agents Chemother, 2002, 46(4), 1022-1025.
[2] Tsai, J.C., et al. 1996. J. Biol. Chem. 271: 3667-3670. [3] Tirouvanziam, R., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 4628-4633. [4] Ortolani, O., et al. 2000. Am. J. Respir. Crit. Care Med. 161: 1907-1911. |
分子结构图
