BMS-986158CAS号： 1800340-40-2分子式： C30H33N5O2分子量： 495.62描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)
| 产品描述 | |
| 描述 |
BMS-986158 is an inhibitor of the bromodomain and extra-terminal (BET) proteins.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO : 50 mg/mL (100.88 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
BET
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| In vitro(体外研究) |
BMS-986158 is an inhibitor of the bromodomain (BRD) and extra-terminal domain (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth.
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分子结构图
