BMS-986142CAS号： 1643368-58-4分子式： C32H30F2N4O4分子量： 572.60描述纯度储存/保存方法别名可溶性/溶解性In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BMS-986142 is a potent and highly selective reversible inhibitor of Bruton’s tyrosine kinase (BTK) with an IC50 of 0.5 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
BMS986142
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| 可溶性/溶解性 |
DMSO : 125 mg/mL (218.30 mM; Need ultrasonic)
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| 生物活性 | |
| In vitro(体外研究) |
BMS-986142 potently inhibits human recombinant BTK with an IC50 of 0.5 nM in enzymatic assays. Against a panel of 384 kinases, BMS-986142 is highly selective, with only five other kinases (Tec, ITK, BLK, Txk, BMX) inhibited with 50=10 nM) is inhibited with 50>10,000 nM for both). When Ramos B cells are treated with anti-IgM to activate BCR, BMS-986142 inhibits BTK-dependent calcium flux with an IC50 of 9 nM.
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| In vivo(体内研究) |
BMS-986142 potently inhibits human recombinant BTK with an IC50 of 0.5 nM in enzymatic assays. Against a panel of 384 kinases, BMS-986142 is highly selective, with only five other kinases (Tec, ITK, BLK, Txk, BMX) inhibited with 50=10 nM) is inhibited with 50>10,000 nM for both). When Ramos B cells are treated with anti-IgM to activate BCR, BMS-986142 inhibits BTK-dependent calcium flux with an IC50 of 9 nM.
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分子结构图
