BMS-986141CAS号： 1478711-48-6分子式： C27H23N5O5S2分子量： 561.63描述储存/保存方法靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614 exhibits significant antithrombotic effects.
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 生物活性 | |
| 靶点 |
PAR4:2.2 nM
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| In vitro(体外研究) |
With an IC50 value of 2.2 nM, BMS-986141 (compound 49) inhibits platelet aggregation induced by PAR4 agonist peptide in a concentration-dependent manner, ranging from 0 to 1 μM[1].
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| In vivo(体内研究) |
BMS-986141 (compound 49), administered at a dose of 0.5 mg/kg, demonstrates excellent anti-thrombotic efficacy in cynomolgus monkeys. Additionally, it shows a slight but significant prolongation of KBT (kidney bleeding time)[1][2].
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