MCB-613CAS号： 1162656-22-5分子式： C20H20N2O 分子量： 304.39描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
MCB-613 is a potent steroid receptor coactivator (SRC) stimulator.
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| 纯度 |
＞98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
体外:
DMSO 60mg/mLwarming(197.11mM) Ethanol 60mg/mLwarming(197.11mM) Water <1mg> 4%DMSO+30%PEG300+ddH2O 2mg/mL |
| 生物活性 | |
| 靶点 |
SRC
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| In vitro(体外研究) |
MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs’ interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS).
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| In vivo(体内研究) |
In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less.
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| 参考文献 | |
| 参考文献 |
[1] Wang L, et al. Cancer Cell. 2015, 28(2), 240-252. |
分子结构图
