WAY-262611CAS号： 1123231-07-1分子式： C20H22N4分子量： 318.42描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
WAY262611; WAY 262611
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO : ≥ 42 mg/mL (131.90 mM)
|
| 生物活性 | |
| 靶点 |
(beta)-catenin
|
| In vitro(体外研究) |
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
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| In vivo(体内研究) |
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1.
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分子结构图
