GM6001 (galardin, ilomastat)是泛MMP抑制剂，对MMP-1，MMP-2，MMP-3，MMP-7，MMP-8，MMP-9，MMP-12，MMP-14和MMP-26的Ki为0.4-27 nM。

＞98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

伊洛马司他；Ilomastat；Galardin

off-white powder

DMSO : 38.9 mg/mL (100 mM)

MMP-8 ,MMP-9 ,MMP-26 ,MMP-1 ,MMP-2

GM6001 inhibits human skin fibroblast collagenase with Ki of 0.4 nM when assayed with a synthetic thio ester substrate at pH 6.5, with 50-fold selectivity over two bacterial enzymes, thermolysin and Pseudomonas aeruginosa elastase. GM 6001 (0.1 nM – 10 nM) inhibits gelatinase A and gelatinase B produced by T-cells, thus inhibits T-cell homing.

Topical application of GM6001 (400 μg/ml) prevents corneal ulceration after severe alkali injury. In rabbit model after stenting, GM6001 significantly inhibits intimal hyperplasia and intimalcollagen content, and it increases lumen area in stented arteries without effects on proliferation rates.