D159687CAS号： 1155877-97-6分子式： C21H19ClN2O2分子量： 366.84描述纯度储存/保存方法别名可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
D159687 is a selective PDE4D inhibitor.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
D 159687
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| 可溶性/溶解性 |
DMSO : 150 mg/mL (408.90 mM; Need ultrasonic)
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| 生物活性 | |
| 靶点 |
PDE4D
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| In vitro(体外研究) |
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM.Western Blot AnalysisCell Line:HT-22 (mouse hippocampal cell line)Concentration:1 μMIncubation Time: 0, 1, 3, 6, 12, 24 hoursResult:Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.
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| In vivo(体内研究) |
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.
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分子结构图
