Mouse Monoclonal Antibody (Mab)

DISC1抗体;Disrupted in schizophrenia 1 protein; DISC1; KIAA0457

Mouse

This DISC1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 701-728 amino acids from human DISC1.

Human

WB~~1:100~250

Predicted molecular weight: 94kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Monoclonal Antibody

584CT4.2.1

IgM

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Neuroscience

Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity) Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome

Q9NRI5

Park, Y.U., et al. Proc. Natl. Acad. Sci. U.S.A. 107(41):17785-17790(2010)
Raznahan, A., et al. Mol. Psychiatry (2010) In press :
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Kaibuchi, K., et al. Nihon Shinkei Seishin Yakurigaku Zasshi 30(3):149-152(2010)
Shulman, J.M., et al. PLoS ONE 5 (6), E11244 (2010) :